New insights into membrane potential
关于膜电位的新认识

摘要

膜电位在现代生物科学特别是神经生物学领域具有相当重要的地位，通过对膜电位测定实验的分析发现，其方法学本质上并不是生理学实验而是电化学实验，由此得出的结论具有一定的狭隘性。经过理论推导，我们对膜电位有了新的认识：K⁺、Na⁺、H⁺的弥散电位代数和才是即时静息膜电位。细胞应激时可以发生动作电位，届时的离子通道就是届时的细胞膜通透性，而离子通道的门控就是细胞膜允许通透时的届时电化学驱动力。所谓离子泵是能量代谢中的某种化合物的中间状态，ATP是关键，不能用一个泵字来解释与ATP有关的一切现象。

Abstract

Membrane potential plays an important role in modern biological science, especially in the field of neurobiology. Through the analysis of the measurements of membrane potential, it is found that its methodology is not a physiological experiment but an electrochemical experiment in essence, and the conclusions drawn therefrom are somewhat narrow. Through theoretical deduction and analysis, we have a new understanding of membrane potential: the algebraic sum of diffusion potential of K+, Na+, H+ is the real-time resting membrane potential; action potential can occur when cells are stressed, and at that time, the ion channel is the permeability of cell membrane, the energy metabolism is the gated ion channel, and the gating of ion channels is the driving force when cell membranes allow permeability. Meanwhile, ATP is the key, the ion pumps are intermediate states of certain compounds involved in energy metabolism, which can not explain all phenomena related to ATP.